Insomnia should be assessed and if present treated with insomnia focused therapy in patients reporting post COVID-19 related chronic fatigue. Conclusion(s) Insomnia severity and prevalence of clinical insomnia is high in PCRF. The PCRF group reported a significantly shorter sleep duration than the CFS/ME group (p = 0.002), with a moderate effect size (d = 0.59). In PCRF the mean subjective sleep duration in h was 7.39 (1.00), sleep onset latency 0.97 (0.62) and wake after sleep onset 1.24 (0.72). Insomnia severity was significantly associated with depressive symptoms (beta = 0.49, p = 0.006) and higher age (beta = -0.08, p = 0.04). Both did not differ significantly from CFS/ME. ABSTRACT Given the high prevalence of sleep disorders (e.g. Result(s) In PCRF patients the mean (SD) insomnia severity was 11.46 (5.7) and prevalence of clinical insomnia was 64%. Sleep characteristics assessed with sleep diary and accelerometer were determined in patients with PCRF and compared with CFS/ME patients using ANCOVA. Linear regression analyses were used to evaluate if fatigue severity, concentration problems, pain, depressive symptoms and having PCRF or CFS/ME were associated with insomnia severity. Method(s) In this cross-sectional study insomnia severity, assessed with the Insomnia Severity Index (ISI), and prevalence of clinical insomnia (ISI score >=10), were determined in patients with PCRF (n = 114) and compared with CFS/ME patients (n = 59) using ANCOVA and logistic regression, respectively. Data of PCRF patients were compared with those of patients with chronic fatigue syndrome (CFS/ME), a condition also characterized by persistent fatigue. The main object of this study was to determine the prevalence of insomnia in patients with PCRF and investigate their sleep characteristics. As these symptoms have overlapping features, insomnia can be easily underdiagnosed in post COVID-19 related fatigue (PCRF). Nonetheless, this study provides evidence that chronic insomnia and hypersomnia are possible symptoms associated with long COVID.ABSTRACT Aims: Following COVID-19 a substantial number of patients report persistent fatigue and insomnia. However, this study was limited by selection bias, as the recruitment method may have resulted in patients with more severe symptoms participating in the study. In performing objective sleep measurements, two patients were identified with central hypersomnia and one with narcolepsy. The first and only non-covalent (reversible) BTK inhibitor, Jaypirca has been shown to extend the benefit of BTK inhibition. Interestingly, most patients had these sleep disorder symptoms persist up to 18 weeks. Insomnia (22.2%) and excessive sleepiness (3.17%) were the most commonly identified sleep disorders in this patient group. Overall, this study identified 48 long COVID (25.3%) patients to have sleep-related symptoms. Questionaries and structured psychiatric interviews were completed to collect sleep symptoms and establish sleep disorder diagnoses. Polysomnography and actigraphy were completed for objective sleep measures. Patients were included if they had a documented SARS-CoV-2 PCR assay and persistence of symptoms for longer than 4 weeks. Patients were recruited via radio messaging and social media. This prospective cohort study included 207patients with post-COVID symptoms at a neurology center in CearĂ¡, Brazil. This study looked to quantify the prevalence of sleep disorders in a cohort of patients with post-COVID symptoms. Of the proposed mechanisms for this, a prolonged latent inflammation and glymphatic congestion have been postulated. Often, these symptoms included fatigue and shortness of breath however, it has been identified that sleep disorders may present with long COVID. People call Long COVID by many names, including Post-COVID Conditions, long-haul COVID, post-acute COVID-19, long-term effects of COVID, and chronic COVID. Long COVID is a persistence of symptoms related to a COVID-19 infection that last beyond 4 weeks.
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